MAPK8 and familial pancreatic carcinoma: In bladder cancer, activated JNK signaling is associated with increased METTL3 expression, and JNK knockdown impairs the binding of c-Jun to the METTL3 promoter, thereby reducing RNA m6A expression levels [174].In pancreatic cancer, a model of smoke condensate-induced malignant transformation of pancreatic ductal epithelial cells demonstrated that smoke condensate-induced METTL3 promoter hypermethylation leads to elevated METTL3 levels [27].