RAC2 (Family Small GTPase 2) is an important neutrophil component of the NADPH oxidase (NOX) multi-protein complex and regulates generation of oxidative stress (OS) reactive oxidative species (ROS), superoxide (O2−) and hydrogen peroxide (H2O2), which are demonstrated in animal and in vitro models of epilepsy [64, 66]. This evidence concerns the gene RAC2 and epilepsy.