Inhibition of F2R is neuroprotective, anti-epileptic, reduces SE (status epilepticus)-induced cell loss, rescues SE-induced hippocampal CA1 region synaptic plasticity, increases hippocampal neuronal cell survival, suppresses interictal spikes and decreases behavioral seizures after SE, decreases mortality, and decreases the occurrence of epilepsy in experimental temporal lobe epilepsy [104, 106, 108]. The gene discussed is F2R; the disease is temporal lobe epilepsy.