Similarly, in a transgenic model of murine temporal lobe epilepsy, knockdown of microglia PKCδ eliminates the microglial proinflammatory inflammogen-induced response and decreases release of proinflammatory mediators, TNF-α, IL-1β, IL-6, and IL-12, reducing electrographic non- convulsive seizure frequency, epileptiform spiking and neuronal degeneration [36]. The gene discussed is TNF; the disease is temporal lobe epilepsy.