Given the increased expression of GATA3, downregulation of PTEN, enrichment for PI3K/AKT/mTOR signaling, and in vitro dependence on this pathway for tumor cell survival and proliferation, canine CD4+ PTCL appears to most closely resemble the GATA3-PTCL subtype of human PTCL-NOS, which may allow for a more specific application of the proposed canine model for this disease. This evidence concerns the gene AKT1 and neoplasm.