CD4 and neoplasm: The first group was characterized by strong enrichment of tumor cells for early T-lymphocyte gene signatures, intrathymic T progenitor cells, and genes upregulated in DP thymocytes compared to naïve circulating CD4+ T-cells and variable enrichment for CD4 SP thymocyte gene signatures, while also seeming to be enriched for genes upregulated with Th1 and Th2 cell activation despite this upregulation of early thymocyte gene signatures.