CD4 and T-cell and NK-cell neoplasm: The correlation between GATA3 upregulation and enrichment for PI3K/AKT/mTOR signaling both in human GATA3-PTCL and canine CD4+ PTCL could reflect a molecular connection between these factors, a finding suggested by a previous study noting that GATA3 target genes in both immature and mature T-cell neoplasms consistently included genes involved in PI3K/AKT signaling [16].