Canine CD4+ PTCL also tended to upregulate other genes associated with the GATA3-PTCL subtype (such as IL18R1, CCR4, CAT, and ACKR3) and downregulate other genes associated with the TBX21-PTCL subtype (such as IFNG, IL2RB, EOMES, and CCL3) compared to other canine PTCL phenotypes and control canine CD4+ and CD8+ lymphocytes. Here, CD4 is linked to mature T-cell and NK-cell non-Hodgkin lymphoma.