MMP3 and colorectal carcinoma: Then, univariate Cox regression analysis selected 9 prognostic OS-associated genes (STK25, CTNNB1, HSPB1, MMP3, SFPQ, RNF112, NOL3, PAGE4, NCOA7) in CRC based on the relation between genes and overall survival of CRC patients in TCGA database (Fig. 2A).