Then, univariate Cox regression analysis selected 9 prognostic OS-associated genes (STK25, CTNNB1, HSPB1, MMP3, SFPQ, RNF112, NOL3, PAGE4, NCOA7) in CRC based on the relation between genes and overall survival of CRC patients in TCGA database (Fig. 2A). The gene discussed is STK25; the disease is colorectal carcinoma.