A similar effect of obesity was detected in mRNA for Slc38a9, an amino acid (arginine) sensor on lysosomes which aides in mTORC1 regulation [57], and disassembly of the lysosomal-folliculin complex allowing FLCN GAP activation of RagC [65]. This evidence concerns the gene SLC38A9 and obesity due to melanocortin 4 receptor deficiency.