We demonstrated differential expression of HSP90AA1 and HSPA8 in non-malignant ovarian tumor tissues, high-grade serous ovarian cancer samples, non-malignant ovarian samples concomitant with diabetes, and diabetes concomitant with high-grade serous ovarian cancer samples through Immunohistochemistry (IHC) and RT-qPCR. The gene discussed is HSPA8; the disease is ovarian neoplasm.