In studies validated without Hardy-Weinberg principle, there was an association between AGTR1 polymorphism and risk of cardiomyopathy with pooled ORs of 0.595 (allelic model, A vs C: 95% CI = 0.451–0.785; P = 0.008) and 0.492 (dominant model, AA+CA vs CC: 95% CI = 0.369–0.1655; P = 0.001). This evidence concerns the gene AGTR1 and cardiomyopathy.