In studies validated without Hardy-Weinberg principle, there was an association between ACE I/D variants and risk of cardiomyopathy with pooled ORs of 1.647 under the allelic model (D vs I: 95% CI = 1.138–2.384; P = 0.008) and 2.433 under dominant model (DD + ID vs II: 95% CI = 1.151–5.142; P = 0.020). This evidence concerns the gene ACE and cardiomyopathy.