ACE and familial dilated cardiomyopathy: Additionally, associations were detected between ACE I/D variants and DCM risk under the allelic and recessive models, with pooled ORs of 1.287 (D vs I: 95% CI = 1.043–1.588; P = 0.019), 0.746 (DD vs ID + II: 95% CI = 0.577–0.965; P = 0.025), respectively.