Therefore, a previous study demonstrated that angiotensin II (AngII) could bind to AngII type 1 receptor on VSMC to activate signal transducer and activator of transcription 3 (STAT3), which in turn promoted the proliferation and migration of VSMC, thus representing the key events in hypertension-induced vascular lesions [2]. The gene discussed is STAT3; the disease is hypertensive disorder.