However, markers in the hedgehog signalling pathway such as PTCH1/2, HHIP, EPCAM, a diagnostic marker for BCC (42), and IGKC, a immunologic marker of solid cancer (43), were highly expressed in BCC basal keratinocytes compared to healthy (SI Appendix, Fig. S8D). This evidence concerns the gene PTCH1 and skin basal cell carcinoma.