By inhibiting the activation of FOXO3a, it can reduce the expression of Muscle Atrophy F-box (MAFbx) and Muscle Ring Finger-1 (MuRF1) mRNA, thereby preventing the degradation of muscle proteins, increasing the cross-sectional area of muscle fibers, and improving the degree of skeletal muscle atrophy; [34] (2) Acupuncture can improve the level of mitochondrial fission and fusion. Here, FOXO3 is linked to Skeletal muscle atrophy.