EGF and hepatocellular carcinoma: It is frequently upregulated in several cancers, including hepatocellular carcinoma [80], gastric cancer [81, 82], glioblastoma [83], medulloblastoma [84], B cell malignancies [85], etc. This transmembrane receptor family contains extracellular epidermal growth factor-like (EGF) repeats domain, with several intracellular domains [86].