Despite the missing correlation between TGase 2 activity and cell binding of [18F]7b, we hypothesized that the activity status of tumor-associated TGase 2 in vivo might be altered and is ideally higher to that in cell monolayers, considering in particular the formation of a tumor microenvironment at the tissue level (Lee et al. 2015). This evidence concerns the gene TGM2 and neoplasm.