Important interaction pairs associated with the CD45 signaling pathway in the RA group were exclusively contributed by Ptprc-Cd22, whereas important interaction pairs associated with the CD45 signaling pathway in the control group were mainly contributed by Ptprc-Mrc1, with Ptprc-Cd22 contributing only a very small fraction (Fig. 7H, I). Here, CD22 is linked to rheumatoid arthritis.