Additionally, there is proof that the immunological and non-immune constituents of the TME interact extensively, whereas the efficacy of adoptively transplanted tumor-specific CD8 + T cells in a syngeneic murine model of lung cancer is increased by the overexpression of superoxide dismutase (SOD3) in endothelial cells (EC) and the consequent stabilization of HIF-2α rather than HIF-1α [67]. Here, EPAS1 is linked to neoplasm.