ENPP1 and nephrocalcinosis: When Abcc6−/− and Enpp1−/− mice (two established mouse models of ectopic mineralization) were placed on the acceleration diet, they revealed extensive mineralization in the kidney interstitium, primarily affecting the medullary tubules as well as arcuate and renal arteries, whereas when on standard rodent diet, developed nephrocalcinosis only at very late age [24], which may explain why nephrocalcinosis rarely occurs in infants.