HIF1A and colitis: Deletion of HIF-1α in myeloid cells ameliorated experimental colitis,81 whereas conditional knockout mice for dendritic cells showed worsened colitis.82 Similarly, deletion of HIF-1α impairs neutrophil metabolism, bactericidal activity, and motility.83 Here, we showed that deletion of HIF-1α in RORγt+ ILC3s impaired murine mucosal defenses after HBO therapy and aggravated C. difficile infections.