HIF1A and clostridium difficile infection: Butyrate-treated Hif-1αΔRorc mice showed greater weight loss, higher clinical score (Figure 7c), shorter colon (Figure 7d), and greater bacterial translocation (Figure 7e) during CDI than butyrate-treated wild-type mice, indicating that the beneficial effect of butyrate on ILC3 and T cells in CDI is HIF-1α dependent.