TP53 and neoplasm: TAp63 is a potent tumor and metastasis suppressor (13) and can regulate the expression of p53-regulated target genes, such as Cdkn1a, Bax, and Lkb1 (12, 14, 15), as well as p53-independent genes, including both noncoding genes, such as a group of 9 long noncoding RNAs called TROLLs (16), as well as protein-coding genes, such as Iapp, Smarcd3, and Dicer (13, 17, 18).