Single-twitch and tetanic stimulation of extensor digitorum longus (EDL) muscle showed a similar reduction of maximum force in single-channelopathy (ClC-1–/–, Figure 1, D–F, blue) and bi-channelopathy (CaV1.1Δe29 ClC-1–/–, Figure 1, D–F, red) muscle as compared with WT mouse muscle (Figure 1, D–F, black) and CaV1.1Δe29 (Figure 1, D–F, orange) controls. Here, CAV1 is linked to channelopathy.