Since acute exposure to verapamil had also reduced transient weakness and myotonia in single-channelopathy ClC-1–/– muscle and 9-AC–treated WT muscle ex vivo (see above), in the context of WT (+e29) CaV1.1, we also examined ClC-1–/– mice before and after 2 weeks of 100 and 200 mg/kg/d verapamil administration by oral feeding. This evidence concerns the gene CACNA1S and Myotonia.