Comparing the integrated normalized force production, myotonia was significantly less severe in 9-AC–treated WT and CaV1.1Δe29 muscles (Figure 4F) as compared with the genetic counterparts (ClC-1–/– and CaV1.1Δe29 ClC-1–/–) (Supplemental Figure 9E; see comparative analysis in Supplemental Figure 10). The gene discussed is CLCN1; the disease is Myotonia.