Interestingly, although the Cav1.1Δe29/+ ClC-1–/– bi-channelopathy mice were severely affected, they did not show all of the hallmarks of DM1 skeletal muscle, suggesting that the effect of CUGexp RNA disrupted the expression of additional genes that contribute to DM1 myopathy (14). The gene discussed is CLCN1; the disease is myotonic dystrophy type 1.