Further, in sperm from a proven father heterozygous for the deletion of CATSPER2 (CATSPER2+/–), CatSper-mediated membrane currents as well as motility parameters were unaffected (Supplemental Figure 9), supporting fully penetrant autosomal-recessive inheritance of CATSPER2-related infertility. The gene discussed is CATSPER1; the disease is Infertility.