ROCK2 has therefore been implicated in the pathogenesis of various vascular diseases, including hypertension (Rankinen et al., 2008; Abd-Elrahman et al., 2015; Hartmann et al., 2015), age-related vascular dysfunction (Nunes and Webb, 2021), hypoxia-induced pulmonary hypertension (Shimizu et al., 2013), as well as vascular dysfunction associated with diabetes (Soliman et al., 2012; Çiçek and Ayaz, 2015) and stroke (Lee et al., 2014; Hiroi et al., 2018). The gene discussed is ROCK2; the disease is stroke disorder.