Briefly, the authors observed several subgroups of tau deposition patterns: a tau pattern most accurately described by elevated limbic tangle deposition (S1, 33% of the AD sample), a predominant posterior occipital and gradually anterior expanding type (S3, 30%), a hemispheric dominant temporo-parietal phenotype (S4, 19%) and, finally, a medial temporal sparing phenotype, with dominantly parietal lobe involvement (S2, 18%). Here, MAPT is linked to Alzheimer disease.