The gene encoding pro-inflammatory cytokines such as IL-1, IL-2, IL-6, Tumor necrosis factor (TNF)-α, and Monocyte chemoattractant protein (MCP)-1 play significant roles in increasing the risk of chronic diseases such as asthma, atherosclerosis, and rheumatoid arthritis (5, 26). This evidence concerns the gene IL1B and atherosclerosis.