While the absence of gigaxonin in patients suffering from a neurodegenerative disease called GAN induces an abnormal accumulation of several IF types (Lescouzères and Bomont, 2020), its overexpression has been shown to induce the clearance of several IF types, including the NF-L, NF-M, NF-M, peripherin and α-internexin (Israeli et al., 2016). Here, NEFM is linked to neurodegenerative disease.