Indeed, depletion of NF-L through genetic manipulation (Zhu et al., 1997), in a spontaneous quail line (Sakaguchi et al., 1993) and in CMT patients with recessive mutations in the NEFL gene (Sainio et al., 2021) substantially inhibits radial growth and nerve conduction. Here, NEFL is linked to Charcot-Marie-Tooth disease.