In this model, standard in-bred mouse strains infected with adeno-associated viral particles containing the human protein convertase subtilisin/kexin type 9 (AAV-PCSK9DY) variant develop hyperlipidemia due to increased recycling of LDL-R from the liver and subsequently will develop atherosclerosis (Roche-Molina et al., 2015; Goettsch et al., 2016). The gene discussed is LDLR; the disease is hyperlipidemia.