AIF1 and Alzheimer disease: For instance, activation of the mechanosensitive Ca2 + channel PIEZO1 in microglia increased the number of ionized calcium-binding adapter molecule 1 (Iba1) positive (+) cells and their co-localization with amyloid beta (Aβ) plaques in the hippocampus of adult male 5xFAD mice, a model of AD pathology (Jäntti et al., 2022).