Additionally, in a GL261 mouse glioma model, 1.5 MHz FUS + microbubbles at 0.43 MPa enhanced the delivery and colocalization of anti-programmed cell death-ligand 1 antibody with glioma cells which promoted antitumor effects by enabling T lymphocytes to target the cancer cells (Ye et al., 2021). This evidence concerns the gene CD274 and central nervous system cancer.