TP53 and cancer: The genes that are reported to be more often linked to cancer phenotypes are TP53, CDKN2A, PIK3CA, NOTCH1, EGFR and CCND1. These genes were found to harbour gross chromosomal abnormalities such as deep deletion, amplification, translocation and single nucleotide substitutions such as missense, nonsense, splice site, and frameshift mutations [1].