In astrocytes, CREB3L1 arrests cells in G2/M phage via transcriptionally activating P21 expression 92, while in glioma cell lines, ER stress inducing compounds including tunicamycin or thapsigargin induce the expression of CREB3L1, knock-down of CREB3L1 leads to the attenuation of UPR proteins GRP78 and GRP94 and reduced extracellular matrix protein expression except COL1. This evidence concerns the gene CREB3L1 and glioma.