CREB3L1 and neoplasm: Doxorubicin and paclitaxel representing two of the chemotherapeutics have been extensively studied, emerged evidence showed that doxorubicin suppresses tumor cell proliferation via activating CREB3L1 98, while paclitaxel works to elevate ceramide generation to facilitate the translocation of CREB3L1 from ER to Golgi complex 95.