They demonstrated the elevated expression of CREB3L1 in kidneys from human chronic kidney disease (CKD) patients and fibrosis mouse model using the publicly available database Nephroseq, and a large number of cells display nuclei staining for CREB3L1 in the tubulointerstitium, whereas in the tubular epithelial cells of normal human kidney CREB3L1 protein mainly shows cytoplasmic localization. Here, CREB3L1 is linked to fibrosis.