Decreased expression of CREB3L1 is related to high tumor grade and implies a bad prognosis and short survival time for patients with tumors positive for estrogen receptor (ER) and negative for human epidermal growth factor receptor 2 (HER2) (luminal A) and triple negative breast cancer (TNBC) 95, 96. This evidence concerns the gene ERBB2 and triple-negative breast carcinoma.