In addition, somatic mutations in CREB3L1 contribute to osteogenesis imperfecta (OI), while the generation of Fused in sarcoma (FUS)-CREB3L1 and EWS RNA Binding Protein 1 (EWSR1)-CREB3L1 lead to LGFMS and sclerosing epithelioid fibrosarcoma (SEF) respectively. The gene discussed is FUS; the disease is osteogenesis imperfecta.