ABCA1 and posterior cortical atrophy: In PCa tissues from African-Caribbean patients, the amount of ABCA1 (aasociated with cholesterol efflux) was reduced and the expression of SREBP-2 (associated with cholesterol uptake) was increased, and the direction of cholesterol accu-mulation in cancer cells correlated with a more frequent epithelial-mesenchymal transition (EMT) status, which may promote PCa aggressiveness in this way 40.