In addition, transgenic expression of IL-6 in the mouse prostate induced autocrine IL-6 and homeostatic activation of STAT3 in prostate tissues, upregulated insulin-like growth factor (IGF) paracrine secretion, reprogrammed prostate oncogene expression, induced PCa production, and amplified inflammation in the prostate and PPAT 48. The gene discussed is STAT3; the disease is posterior cortical atrophy.