MUC1 and familial pancreatic carcinoma: In a human pancreatic cancer cell model, the cytoplasmic caudal motif of MUC1 directly binds to the promoter region of multidrug resistance (MDR) gene ATP-binding cassette (ABC-C1) gene and upregulates the level of multidrug resistance-associated protein 1 (MRP1) protein encoded by Abcc1 through the Akt-dependent pathway, MRP1-9 is a class of the ABC transporters that have been positively linked to the MDR phenotype in cancer cells.