MUC1-C activates the nuclear factor kB p65(NF-kB p65) pathway in the pro-inflammatory factor Transforming growth factor-b-activated kinase-1 (TAK1) → IkB kinase (IKK) cancer cells or directly binds to NF-κB p65 to drive its downstream target genes42, inducing the epithelial-mesenchymal transformation (EMT) in basal B cells43. Here, NFKB1 is linked to cancer.