IGFBP5 and central nervous system cancer: Next, we analyzed the correlation between IGFBP5 expression and tumor-infiltrating immune cell status based on the expression levels of immune marker gene in glioma using the CGGA and TCGA databases, including B cells, T cells, CD8+ T cells, monocytes, tumor-associating macrophages (TAMs), macrophages, neutrophils, natural killer (NK) cells and dendritic cells.