To study the correlation between IGFBP5 expression and WHO grade for glioma, we analyzed the data from TCGA, Rembrand, Gravendeel and CGGA cohorts and the results discoursed that IGFBP5 expression was gradually increased responding to tumor grade through II-IV in these four datasets (Figure 1C). The gene discussed is IGFBP5; the disease is glioma.