Importantly, IGFBP5 expression was closely correlated with clinical and prognostic outcomes in glioma using the TCGA, CGGA, Rembrandt, and Gravendeel datasets, including age, tumor grade, IDH mutation status, Histological type, and chromosome 1p/19q co-deletion status, as well as with Primary therapy outcomes. This evidence concerns the gene IGFBP5 and neoplasm.