In this study, we found that IGFBP5 knockdown significantly inhibited glioma cell proliferation, migration and invasion, while IGFBP5 overexpression promoted glioma cell proliferation, migration and invasion Knockdown IGFBP5 expression inhibited EMT and MMP-2 expression, while increasing IGFBP5 expression promoted EMT and MMP-2 expression, which indicated that IGFBP5 facilitated glioma cell migration and invasion involved in EMT and MMP expression, which is consistent with the part results of the prevoius study 11. The gene discussed is MMP2; the disease is central nervous system cancer.