MBTPS1 and melanoma: Interestingly, moderate aerobic physical exercise, conducted in melanoma carrying male C57BL/6J mice, was reported to increase ceramide levels and activate the pro-apoptotic p53 signaling pathway, hence highlighting its efficacy as adjuvant therapy by modulating sphingolipid metabolism toward a pro-apoptotic ceramide signaling, at the expense of S1P activity 60.