Indeed, post-implant exercise alone (on running wheels associated with a digital count of revolutions) was found to significantly decrease the number of tumor resident CD8+ T cells in a breast cancer in vivo model (EO771 cells in female C57BL/6 mice), but not in the case of melanoma (B16F10 cells in female C57BL/6 mice). This evidence concerns the gene CD8A and melanoma.