EPO and injury: In addition, a series of evidence suggest that erythropoietin (EPO) can improve cognitive function by protecting hippocampal neurons from hypoxia-induced oxidative damage, further confirming that hypoxia-induced hippocampal damage is associated with long-term brain dysfunction, and these findings are helpful in exploring the crosstalk between acute lung injury and distal brain injury (Dayyat et al., 2012; Jacobs et al., 2021).