We must also consider the impacts of other factors that affect S NfL levels (e.g., body mass index, renal function, blood volume, high-density lipoprotein, etc.)and are associated with increased risk of vascular disease (Koini et al., 2021), given that Group 2 also included several patients with vascular dementia classified as non-Alzheimer dementia (Román, 2005). The gene discussed is NEFL; the disease is Alzheimer disease.