Blocking the TGF-β signal (DC20Gy/TGFβi/U14) significantly promoted the homing of DCs pulsed by tumor secretions, whereas simultaneous blockade of PGE2 signaling (DC20Gy/TGFβi+PGE2i/U14) overrode this stimulatory effect, resulting in most DCs remaining localized in the footpad (Fig. 5 B and C). This evidence concerns the gene TGFB1 and neoplasm.