Cho et al. 91 showed that the cGAS-STING-TBK1 pathway was activated and mediated p62 phosphorylation and protein inclusions (a critical marker of NASH) in saturated fatty acid (SFA)-treated homoplastic hepatocytes and HFD-fed obese mice. The gene discussed is STING1; the disease is metabolic dysfunction-associated steatohepatitis.