Inhibiting TBK1 by administering amlexanox or knocking out the TBK1-encoding gene significantly alleviated hepatic steatosis by decreasing fat accumulation, lipogenic gene expression, proinflammatory cytokine levels and macrophage infiltration in the livers of HFD-fed mice or ob/ob mice 80,81. Here, TBK1 is linked to Hepatic steatosis.