We, therefore, transfected siRNA targeting FBXL7 and XIAP to CNE2 cells and found that restoration of survivin protein only in FBXL7-silenced (Fig. 5G), but not XIAP-silenced (Fig. 5H) CNE2 cells following IR treatment, indicating that FBXL7 play a crucial role in IR-reduced survivin expression in NPC cells. This evidence concerns the gene FBXL7 and nasopharyngeal carcinoma.