Differentially expressed genes (DEG) were selected (|log2FC|≥1, P<0.05), and their enriched signaling pathways were identified (Fig. 4A, Table S3), showing that KLF7 regulated several signaling pathways associated with cancer, including MAPK/ERK, RAS, JAK/STAT3, and PI3K/AKT (Fig. 4B, Table S4). The gene discussed is STAT3; the disease is cancer.