Interestingly, compared to traditional fatty liver models such as HFD feeding, chronic alcohol feeding, and leptin gene deletion, Gao et al. have developed a mouse model of acute steatohepatitis (HFD-plus-binge ethanol model) and successfully demonstrated hepatic PPARγ was found to induce steatosis through the upregulation of fat-specific protein 27 (Fsp27) and concurrently mitigate neutrophil infiltration by suppressing CXCL1, a chemokine involved in neutrophil recruitment100. This evidence concerns the gene CIDEC and steatosis.