Various factors can induce pyroptosis, which is typically activated by injury or pathogen-associated molecular patterns that stimulate the NOD-like receptor family pyrin domain-containing protein 3 (NLRP3), bacterial infection that induces the CARD-containing NLR family protein 4 (NLRP3), activation of the NLR-family CARD-containing protein 4 (NLRC4) in response to bacterial infection, and the absence of the PYHIN family member in melanoma 2 (AIM2) in response to abnormal double-stranded DNA. This evidence concerns the gene AIM2 and bacterial infectious disease.