ACE and Hypercholesterolemia: Clinical treatments to reduce fibrosis of cardiovascular patients are not antifibrotic drugs but antihypertensive agents such as angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor antagonists (ARA-II) 22 or drugs against hypercholesterolemia such as statins 23, but in no case are they designed to reduce fibrosis itself.