APP and neuroblastoma: To test the effect of ALT001 on AD, we first examined whether ALT001 can ameliorate mitochondrial dysfunction in SH-SY5Y human neuroblastoma cells expressing the APP Swe/Ind mutant, a cellular model of AD, after verification of alternative pathway-dependent mitophagy induction by ALT001 in SH-SY5Y cells (Figure S5A-F).