Here, we report a novel function of VDBP, which interacts with Twist1, a key epithelial-mesenchymal transition (EMT) transcription factor, to inhibit vasculogenic mimicry (VM), a form of angiogenesis found in many malignancies that is not dependent on vascular endothelial cells in HCC 9. The gene discussed is GC; the disease is hepatocellular carcinoma.