To accommodate the demands of escaping from immune surveillance and co-loading CsA and miR-modulators with fewer side effects, inspired by the ability of CD47 expressed on tumor cells emitting a “don't eat me” signal to macrophages and human antigen R (HuR) interacting with AU-rich elements (AREs) to bind target RNA 18,19, we established a nimbly reprogrammed Exos wearing the CD47 “camouflage cloak” and grafting the “AREs-magnetism” HuR. This evidence concerns the gene CD47 and neoplasm.