TAC1 and Pruritus: First, we found that these neurons were predominantly located in lamina II (7/7) rather than lamina III (0/7) of the dorsal horn of the spinal cord, which suggests that Tac2 neurons in the lamina II expressing Y1Rs may be the same group of neurons as Tac2 neurons in the lamina II with increased activity identified in the AEW chronic itch model 10.