Brady et al. found that endosialin was mainly expressed in highly invasive glioblastoma multiforme, anaplastic astrocytomas and metastatic carcinomas; and endosialin was localized to the endothelium of small and large vessels, Thy-1-positive fibroblast-like cells and α-smooth muscle actin (α-SMA)-positive cells 22. The gene discussed is CD248; the disease is metastatic carcinoma.