CD248 and sarcoma: For immunotoxin, Guo et al. generated an immunotoxin through conjugating the anti-endosialin 78Fc, which contains scFv78 and Fc fragment, with saporin (78Fc-Sap) and confirmed that 78Fc-Sap was effective in killing endosialin-positive sarcoma cells in vitro and could eliminate human sarcoma xenografts without apparent toxicity in vivo32.