CD248 and neoplasm: Rouleau et al. conjugated a human anti-endosialin antibody with the anti-neoplastic agent MMAE through the maleimidocaproyl-valine-citrulline-p-aminobenzylcarbamate linker (so-called endosialin-MC-VC-PABC-MMAE) and demonstrated that the ADC had selective cytotoxicity to endosialin-positive cells in vitro and achieved profound and durable antitumor efficacy in human tumor xenograft models 84.