CD248 and neoplasm: Facciponte et al. immunized immunocompetent mice with endosialin cDNA fused to the minimal domain of the C fragment of tetanus toxoid (referred to as the Tem1-TT vaccine) and demonstrated that Tem1-TT vaccination could elicit CD8+ and/or CD4+ T-cell responses, reduce tumor vascularity, increase CD3+ T-cell infiltration, and control the progression of established tumors.