EPAS1 and neoplasm: In colorectal cancer (CRC), O'Shannessy et al. found that stromal expression of endosialin had prognostic value, and signature combining endosialin expression score with other compartment-specific expression scores (endosialin stroma, endosialin tumor vessel, HIF2α stromal vessel, Col IV tumor, and FN stroma) had even better prognostic value, specifically in stage II CRC patients 26.