In breast cancer, Huang et al. constructed a bone metastasis-specific regulatory network based on prognostic stemness-related signatures (PSRSs), their upstream transcription factors (TFs) and downstream pathways and found that MAF may positively regulate endosialin expression and that endosialin may influence breast cancer bone metastasis via the apical junction pathway 47. This evidence concerns the gene CD248 and breast carcinoma.