In colorectal cancer (CRC), O'Shannessy et al. found that stromal expression of endosialin had prognostic value, and signature combining endosialin expression score with other compartment-specific expression scores (endosialin stroma, endosialin tumor vessel, HIF2α stromal vessel, Col IV tumor, and FN stroma) had even better prognostic value, specifically in stage II CRC patients 26. This evidence concerns the gene EPAS1 and colorectal carcinoma.