CD248 and neoplasm: It was shown that there was no difference in the growth of subcutaneously inoculated tumors in endosialin KO mice; however, tumor growth, invasiveness and metastasis were significantly inhibited in endosialin KO mice when tumor cells were transplanted in abdominal sites, indicating that endosialin has an anatomical site-specific tumor-promoting function or that the local microenvironment might be involved in endosialin-mediated tumor progression 41.