Injection of the poly(lactic-co-glycolic acid) nanoparticle encapsulating TGF-β into lupus mice induced expansion of CD4+Foxp3+ Treg cells and CD8+Foxp3+ Treg cells and suppression of anti-dsDNA antibody and reduced renal disease (113). The gene discussed is CD4; the disease is systemic lupus erythematosus.