The findings were partly similar to a study from eastern China SLE patients, where SLE patients treated with 1 million IU/day IL-2 (every second day for 2 weeks plus a 2-week break, three cycles) revealed a lower frequency of CD4+CXCR5+ cells and increased ratio of Tfr/Tfh cells (RCTs) (157). This evidence concerns the gene CXCR5 and systemic lupus erythematosus.