SLE patients revealed low SLEDAI score, less myositis, fever, alopecia, vasculitis, arthritis, oral ulcer, and decreased number of CXCR5+PD-1+CCR7lo Tfh cells, CCR6+CXCR3-CCR4+CCR7lo Th17 cells. This evidence concerns the gene PDCD1 and systemic lupus erythematosus.