Moreover, both lipocalin-2 (LCN2) expression in CD4+ T cells from LN patients, LCN2 expression in peripheral blood mononuclear cells (PBMCs), and splenic CD4+ T cells from MRL/lpr mice were higher than those in controls, correlating with SLE disease activity index and urine protein and serum creatinine expression (15). This evidence concerns the gene CD4 and lobular neoplasia.