For low-dose IL-2 treatment in lupus mice, MRL/lpr mice injected with IL-2 (30,000 IU/day for 1 week) reported that lymph nodes were shrunk and the expressions of anti-dsDNA, IFNγ, IL-10, urine protein, and creatinine were inhibited after 1 week treatment and were returned to the pretreatment level 4 weeks later (147). This evidence concerns the gene IL2 and systemic lupus erythematosus.