When BDF1 lupus-like mice were treated with IL-2-loaded poly lactic-co-glycolic acid nanoparticles (IL-2-loaded NPs) targeted to CD3 T cells, the number of immature CD24+IgM+CD21int/lo transitional 2 cells, mature follicular B cells, and Tfh cells was reduced (159). This evidence concerns the gene CD40LG and systemic lupus erythematosus.