There was a low percentage of IL-2-producing CD4+ T cells in SLE patients, and CD4+ T cells from SLE patients stimulated with IL-2 reduced the percentage of pSTAT5+CD4+ T cells and inhibited the proliferation of CD4+ T cells and expression of phosphorylation of JAK3 (144). This evidence concerns the gene CD4 and systemic lupus erythematosus.