On the contrary, (NZB×NZW)F1 mice administrated anti-IL-2 antibody downregulated the percentage of CD4+CD25+Foxp3+ Treg cells in the lymph nodes and spleen, led to acceleration of nephritis, and increased mortality (165), and MRL/lpr mice administrated anti-IL-2 antibody promoted IL-17+ γδ T-cell proliferation (148). The gene discussed is IL2; the disease is nephritis.