CD4 and systemic lupus erythematosus: After adoptively transferring IL-2-stimulated CD4+ɑβ Th1 clones (dna51 (Vβ8.3) and rnp2 (Vβ14)) to MRL/lpr lupus mice or transferring irradiated CD4+ɑβ Th1 clones to lupus mice, serum levels of anti-dsDNA antibody, activity index for LN, and numbers of CD4+Vβ8.3 T cells in spleen were reduced and dna51 cell proliferation and cytotoxicity of CD8+ T cells against dna51 were inhibited as well (16).