These were confirmed in other NPs, by which BDF1 lupus-like mice treated with anti-CD2/CD4 antibody-coated NPs encapsulating IL-2 will lead to a higher number of CD4+ and CD8+ Treg cells, decreased expression of anti-dsDNA, proteinuria, and preserved glomeruli (113). Here, CD8A is linked to systemic lupus erythematosus.