Similarly, FcγRIIb−/− lupus mice treated with etanercept upregulated cancellous bone volume and cortical thickness and downregulated expression of osteoblast marker genes (OSX, Collagen type I α 1) and serum levels of TNFα, IFNγ, IL-6, and IL-17A (92). Here, TNF is linked to systemic lupus erythematosus.