IFNG and systemic lupus erythematosus: Similarly, SLE patients treated with prednisone, cyclophosphamide, mycophenolate mofetil, and methotrexate revealed elevated expression of IFNγ and TBX21 in PBMCs and increased percentage of IFNγ-producing cells, which were related to expression of anti-dsDNA and SLEDAI score (118).