To this end, human monocyte-derived macrophages (MDMs) isolated from three different donors (K1–K3) were incubated with Epidermal Growth Factor Receptor (EGFR+) expressing human colorectal adenocarcinoma DLD-1 cells preloaded with carboxyfluorescein diacetate succinimidyl ester (CFSE) alone or in the presence of the opsonizing EGFR-specific antibody cetuximab and hSIRPαD1-targeting Nbs or the KWAR23 antibody as positive control. Here, EGFR is linked to colorectal adenocarcinoma.