FOXP3 and type 1 diabetes mellitus: Acute Foxp3+ Treg cell ablation recapitulated some, but not all aspects of the scurfy syndrome in non-autoimmune-prone mice (11, 12) and highlighted the continuous requirement of Treg cells to constrain organ-specific autoimmune responses in the spontaneous non-obese diabetic (NOD) mouse model of human type 1 diabetes (T1D) (13).