While Foxp3+ Treg cell-deficient NOD mice fail to develop insulitis and overt diabetes (33), the data depicted in Figure 7 provided the first indications that selective tTreg cell paucity can promote severe insulitis and overt diabetes (32.4%; Figures 7B–E) in both males and females, despite incomplete backcrossing onto the NOD background. Here, FOXP3 is linked to diabetes mellitus.