CST3 and heart disorder: This study showed a decrease in cystatin C as well as serum creatinine, which may indicate improved renal function, because cystatin C is thought to be less susceptible to the tubular transporter inhibitory effects of DTG.24 Cystatin C is a biomarker affected by chronic inflammation, smoking, and heart disease, but none of these factors changed before or after switching to CAB plus RPV LA in this study, and multivariable analysis showed that no baseline characteristics significantly affected the absolute changes in these biomarkers.