To further investigate the impact of these baseline factors on the absolute change in renal function biomarkers, we evaluated the effect of age, BMI, inflammation biomarker (i.e., CD4/CD8 ratio and C-reactive protein), smoking, heart diseases, malignancy and preswitching regimens (i.e., DTG-containing regimen, B/F/TAF use, cobicistat-containing regimen, and other regimens) using multivariable regression analysis. The gene discussed is CD4; the disease is heart disorder.